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- Campus Samambaia, Campus Colemar Natal e Silva, Campus Aparecida de Goiânia.
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Item type: Item , Libertad, natalidad y pluralidad en la comprensión de la acción por Hannah Arendt(2025-05-12) Silva, Adriano CorreiaIn this paper I examine the connection that Hannah Arendt makes between natality, freedom and plurality in her conception of political action. Arendt insists that freedom is only possible under conditions of non-sovereignty and this is because human plurality itself, the precondition and raison d'être of politics, is threatened by the predominance of a single perspective and a single force. The freedom that corresponds to plurality can only be nonsovereign, so that the frailties of action, such as unpredictability, irreversibility, limitlessness and ambiguity are not defects that can be explained by the precarious development of political wisdom, but something that is constitutive of political life.Item type: Item , Exploring the clinical utility of cardiorespiratory optimal point in heart failure patients: creating a new research gap(2025) Silva, Weder Alves da; Sá Filho, Alberto Souza de; Ramos, Plínio dos Santos; Chiappa, Adriana Meira Güntzel; Fernandes, Vicente Aprigliano; Silva, Iransé Oliveira; Cunha, Raphael Martins da; Fajemiroye, James Oluwagbamigbe; Vieira, Rodolfo de Paula; Ferrari, Gerson Luis de Moraes; Chiappa, Gaspar Rogério da SilvaThe cardiorespiratory optimal point (COP) is an emerging submaximal parameter from cardiopulmonary exercise testing (CPET) that reflects the optimal balance between cardiac workload and pulmonary ventilation. Recent studies have explored the clinical utility and prognostic value of the COP in various populations, particularly in patients with heart failure (HF). This comprehensive literature review evaluated the current evidence on the COP and its potential as an independent risk factor for cardiovascular disease and mortality. The COP has been identified as a predictor of all-cause and cardiovascular mortality, with elevated values being significantly associated with an increased risk. Studies have demonstrated that higher COP values correlate with greater mortality risk independent of traditional risk factors, with significant sex-based differences. Evidence suggests that COP values greater than 26 significantly influence mortality rates and lead to a worse prognosis in patients with HF. For example, individuals with a COP > 30 had an approximately six-fold higher mortality risk (17.1%) than those with a COP < 22, and the combination of a high COP (>30) + low VO2max leads to a significant increase in the risks of adverse effects (30.9%). This underscores the importance of the COP in the clinical management and risk stratification of HF patients. While the COP shows promise as a valuable submaximal marker with significant prognostic implications, further research is needed to establish its superiority over other established prognostic markers and elucidate the underlying mechanisms linking the COP to health outcomes. Nonetheless, the ability of the COP to predict mortality and enhance risk stratification in diverse populations makes it a promising tool in clinical practice.Item type: Item , Bridging emotional and intellectual dimensions in translational neuroscience(2025) Fajemiroye, James OluwagbamigbeItem type: Item , Characterization of a novel small chemical entity with anxiolytic- and antidepressant-like effects targeting multiple receptors(2025) Ogbu, John Ihayi; Moreira, Caroline Vitória de Lima; Pereira, Jhon Kennedy Alves; Silva, Kariny P. da; Lião, Luciano Morais; Dietz, Gunnar P. H.; Silva, Mirely Vitória Farias da; Sá Filho, Alberto Souza de; Silva Júnior, Edeildo Ferreira da; Pedrino, Gustavo Rodrigues; Fajemiroy, James OluwagbamigbeEffective restoration of mental health in psychiatric disorders increasingly hinges on bridging neurobiological insights with clinically validated pharmacotherapies. The etiological heterogeneity of anxiety and depression underscores the need for novel compounds capable of modulating multiple neurochemical systems. In this study, we describe the synthesis and detailed characterization of a hydroxyl phenethyl acetamide analog (LQFM334) designed to target key receptors involved in mood regulation. LQFM334 exhibited a favorable safety profile and elicited robust anxiolytic- and antidepressant-like effects in mouse models. These behavioral outcomes were supported by in silico receptor profiling and in vitro functional assays, identifying LQFM334 as a potential agonist at serotonergic (5-HT1A/5-HT2A) and melatonergic (MT1/MT2) receptors. Pharmacological blockades of these receptors, but not of α-adrenergic or dopaminergic receptors, attenuated its behavioral effects. These findings position LQFM334 as a promising multireceptor ligand exemplifying a polypharmacology approach for the treatment of complex psychiatric conditions. The dual serotonergic and melatonergic mechanisms confer strong translational relevance involving the modulation of mood, stress resilience, and circadian rhythms domains that are frequently disrupted in affective disorders. These findings support LQFM334's potential in delivering broad-spectrum and clinically relevant psychiatric symptom relief.Item type: Item , Caffeine combined with excitatory neuromodulation based on transcranial Direct Current Stimulation (tDCS) enhances performance in a time-trial CrossFit® workout: a randomized, placebo-controlled, double-blind study(2025) Sá Filho, Alberto Souza de; Silva, Thiago Albernaz; Inacio, Pedro Augusto Querido; Fernandes, Vicente Aprigliano; Silva, Iransé Oliveira; Chiappa, Gaspar Rogério da Silva; Vieira, Rodolfo de Paula; Aguiar, Antônio Sérgio Nakao de; Cunha, Raphael Martins; Fajemiroy, James OluwagbamigbeBackground: Caffeine (CAF) and transcranial direct current stimulation (tDCS) are ergogenic strategies with potential benefits for performance, yet their combined effects remain underexplored, particularly in high-intensity functional training contexts such as CrossFit®. Objective: This randomized, double-blind, placebo-controlled crossover study aimed to investigate the impact of tDCS, with and without CAF, on performance time in the Clean & Jerk (C&J) during the benchmark WOD GRACE among competitive CrossFit® athletes. Secondarily, we aimed to compare the RPE across the different experimental conditions, as well as to establish the relationship between personal record (PR) values adjusted for body mass and the execution time of the WOD GRACE, considering different athletes’ classification levels (RX Elite and RX Intermediate). Methods: Twenty participants completed four experimental conditions: CAF ingestion (400 mg) combined with anodal tDCS (CAF + a-tDCS), CAF with Sham tDCS (CAF + Sham-tDCS), placebo (PLA) with a-tDCS (PLA + a-tDCS), and PLA with Sham tDCS (PLA + Sham-tDCS). Results: The results indicated that the combination of CAF + a-tDCS significantly improved performance, reducing execution time (205.5 ± 58.0 s) compared to CAF + Sham-tDCS (218.3 ± 61.2 s; p = 0.034), PLA + a-tDCS (231.7 ± 64.1 s; p = 0.012), and PLA + Sham-tDCS (240.9 ± 66.4 s; p = 0.002). However, no significant differences were observed between CAF + Sham-tDCS and PLA + a-tDCS (p = 0.690), CAF + Sham-tDCS and PLA + Sham-tDCS (p = 0.352), or PLA + a-tDCS and PLA + Sham-tDCS (p = 0.595). The responder analysis revealed that 45% of participants improved performance with isolated tDCS, while 60% responded positively to CAF. No significant differences were found in RPE scores among conditions (p = 0.145). Additionally, no correlations were identified between PR values adjusted for body mass and execution time in both RX Elite (r = 0.265; p = 0.526) and RX Intermediate (r = 0.049; p = 0.901) groups, nor between training experience and performance across interventions. Conclusions: These findings suggest that tDCS, when combined with CAF, may serve as an effective ergogenic aid for improving performance in high-intensity functional training, whereas its isolated use does not yield meaningful benefits.