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Item type: Item , Central GABAergic control of cardiac function in different hypertrophy models(2025) Mendonça, Michelle Mendanha; Moraes, Gean Carlos Alves; Ribeiro, Juliana Vila Verde; Moreira, Thalison Rodrigues; Freitas, Isabela Carvalho; Neves, Angela R.; Lopes, Paulo Ricardo; Nalivaiko, Eugene; Fontes, Marco Antônio Peliky; Borges, Clayton Luiz; Gomes, Rodrigo MelloCardiac hypertrophy is the clinical stage that precedes failure, whose pathophysiology relies on peripheral and central mechanisms. To evaluate whether pressure overload and/or cardiac β-adrenergic stimulation are the variables potentially linked to central GABAergic changes, we systematically compared different models of cardiac hypertrophy. Wistar rats (WT, >12 weeks of age) were instrumented for aortic coarctation (COA 30 days) or chronic beta-adrenergic stimulation with isoproterenol (ISO 1 mg/kg/day for 7 days), besides using spontaneously hypertensive (SHR, 14 weeks of age). Echocardiography confirmed hypertrophy in SHR, ISO and COA, with greater diastolic and systolic dysfunctions found in SHR. The inotropic performance of the ISO group was poorly influenced by afterload. In anesthetized rats, we recorded arterial and ventricular pressures before and after intracerebroventricular injection of GABA (200 nmol/2 μL), followed (20 min later) by the inhibitor of glutamate decarboxylase enzyme (GAD65/67), L-allylglycine (LAG – 87 nmol/2 μL). Brains were removed to assess gene and protein expression of the vesicular GABA transporter (VGAT), GAD65/67, and GABA receptor subtypes A (GABAA) and B (GABAB) in the hypothalamus and medulla. GABA reduced pressure and contractility in WT, SHR, ISO and COA groups without affecting chronotropy, while LAG increased chronotropy and inotropy only in ISO. While GAD65/67 and VGAT protein expression remained unchanged, GABAA levels were higher in the hypothalamus of SHR and GABAB were lower in SHR and COA medullary samples. Gene expressions of GABAA, GABAB, GAD65 and VGAT were higher in SHR hypothalamic samples. In conclusion, SHR is the hypertrophy model displaying the greater echocardiographic morphofunctional changes and presenting prominent alterations in hypothalamic and medullary GABAergic components.Item type: Item , Fenofibrate treatment during lactation prevents liver and adipose tissue associated metabolic dysfunction in a rat model of childhood obesity(2025) Saavedra, Lucas Paulo Jacinto; Raposo, Scarlett Rodrigues; Assakawa, Ana Letícia Manso; Lucredi, Naiara Cristina; Peres, Maria Natália Chimirri; Piovan, Silvano; Gonçalves, Gessica Dutra; Moreira, Veridiana Mota; Barbosa, Letícia Ferreira; Sousa, Diana; Gomes, Rodrigo MelloChildhood obesity and associated comorbidities in adulthood are of great concern worldwide. Evidence highlights the importance of lactation in later disease development. In this sense, obese children are at great risk of developing adult obesity, insulin resistance, type 2 diabetes, and cardiovascular disease at adulthood. PPARα activation during lactation promotes the expression of key enzymes involved in lipid oxidation, and it was associated with reduced adiposity in children. Therefore, we hypothesized that an animal model of childhood obesity, small litter (SL), would lead to the development of obesity and metabolic dysfunction in adulthood, which could be prevented by postnatal PPARα agonism. Wistar dams had their litter reduced, leading to postnatal overfeeding and obesity early in life. SL male pups were treated with fenofibrate, an PPARα agonist, during lactation, from postnatal day (PND) 1 until weaning (PND21), to verify whether PPARα activation prevents the developmental programming at adulthood (PND120). Childhood obesity induced by postnatal overfeeding leads to decreased markers for oxidative metabolism during infancy, leading to increased visceral adiposity and oxidative stress, insulin resistance, hepatic microvesicular steatosis, and increased fibroblast growth factor 21 (Fgf21) expression, followed by decreased brown adipose tissue (BAT) sympathetic nerve activity and decreased Fgfr1 hypothalamic expression in adulthood. Agonist-induced PPAR α activation during lactation mitigated the development of aforementioned alterations in adulthood. Postnatal fenofibrate treatment prevents the developmental programming of visceral obesity, liver-associated metabolic dysfunction and BAT autonomic sympathetic hypoactivity in an animal model of childhood obesity.Item type: Item , Pega, picou, vai picar, mamba negra! Um corpo expandido na confluência das Artes Visuais com o vogue femme(Universidade Federal de Goiás, 2025-11-27) Silva, Alessandra Pires dos Santos; Rodrigues, Manoela dos Anjos Afonso; Rodrigues, Manoela dos Anjos Afonso; Silva, Odinaldo da Costa; Santos Júnior, Jocy Meneses dosThis final course research results from the significant experiences I lived throughout my trajectory in the Visual Arts Bachelor’s program, especially those that enabled the encounter between my existence as a Black travesti person, my practices in Visual Arts, and my immersion in Ballroom culture. The research unfolds from my Undergraduate Research project, a moment in which I reflected on how the Vogue Femme expression, originating in Ballroom culture, constitutes an ancestral manifestation of rescue and remembrance of expressions and identities that were historically repressed, fostering self-empowerment and strengthening one’s existence in the world. This trajectory also includes my participation in the Xica Manicongo Collective, through which I contributed to important institutional achievements for the trans and travesti community at the Federal University of Goiás, as well as the organization of actions such as the Trans Visibility Ball. From these experiences, I proposed to discuss an expanded body that creates art at the confluence of Visual Arts and Ballroom culture, establishing a dialogue between painting and performance, in which I understood my body as an active element in the construction of the artwork. Through this approach, I investigated how performative gestures can produce painting and how painting can unfold into action, presence, and movement. This process led me to the concept of expanded body/painting, in which the body not only creates the image but also becomes the very surface and territory of painting, drawing from the expression of Vogue Femme and other elements of Ballroom culture to expand the boundaries between support, gesture, and expression. The methodology adopted is Autobiographical Research in Art, combined with the concepts of Escrevivência and TRANSescrevivência. The objective of this research was to investigate, from an autobiographical perspective, how Ballroom culture in dialogue with Visual Arts can constitute a means of expression and (re)existence in racist, transphobic, and oppressive social contexts. Thus, I sought to stimulate artistic poetics and creative processes inspired by Ballroom culture that could function as a poetic and political process of resistance, in which my story can be told through art.Item type: Item , Plataformas privadas como mecanismo do capitalismo de vigilância: análise dos servidores de e-mail em universidades e institutos federais do Brasil(2025) Lima, Daniela da Costa Britto Pereira; Araújo, Luiz Fernando Gonçalves da Silva; Forte, Luciano ToledoThis study analyzes the use of private email server platforms from Google and Microsoft and their implications in the context of surveillance capitalism. The research, which is quantitative-qualitative in nature, involves bibliographic and documentary analysis with data from the Supervised Education Observatory, revealing a concerning scenario of technological dependence. More than 70% of Federal Universities (UF) in three regions in Brazil use Google servers, while in Federal Institutes (IF), there are other three regions with 100% dependence on this big tech. The presence of Microsoft servers is higher in UF. The results highlight risks to the digital autonomy of these institutions, reinforcing the need for public policies that promote public technological alternatives, preserving education as a common good and a democratic space for knowledge production.Item type: Item , Da técnica às tecnologias de informação e comunicação: ensaio sobre a lógica neoliberal de inserção de tecnologias na educação(2025) Echalar, Jhonny David; Lima, Daniela da Costa Britto PereiraThis essay aims to contribute to the ongoing reflections on the integration of technology in education—an area of study marked by complexity and multiple layers of determination, especially when intersecting with various educational themes. Drawing on Milton Santos' reflections on the development of science, technical objects, and globalization, this essay offers theoretical and conceptual foundations to understand how Information and Communication Technologies (ICTs) have been incorporated into the formulation of educational policies, often guided by the neoliberal agendas of multilateral organizations. Through the interweaving of relationships explored throughout this work, we can discern the influence and impact of neoliberal assumptions—from the meanings ascribed to ICTs to their strategic use in sustaining the social structures of inequality inherent in capitalist society.