2018-10-032018-10-032011-02JUNQUEIRA, Ana Luiza N. et al. Presence of maternal anti-HBs antibodies does not influence hepatitis B vaccine response in brazilian neonates. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 1, p. 113-116, Feb. 2011.e- 1678-8060http://repositorio.bc.ufg.br/handle/ri/16099Recently, it was suggested that maternal hepatitis B surface antigen antibodies (anti-HBs) acquired transplacentally could play a negative role in newborn infants’ immune response to the hepatitis B vaccine. We compared the hepatitis B virus (HBV) vaccine response in infants born to mothers previously vaccinated against HBV (n = 91) to infants born to mothers who were not previously vaccinated (n = 221). All newborn infants received three intramuscular doses (10 μg) of HBV vaccine (Butang®) at 0,1 and six months. The first dose was administered at the maternity hospital within 12 h of birth. The geometric mean titres of anti-HBs were not different among newborn infants born to mothers who were anti-HBs-negative (492.7 mIU/mL) and anti-HBs-positive (578.7 mIU/mL) (p = 0.38). Eight infants did not respond to the HBV vaccine. Of them, six were born to anti-HBs-negative mothers and two were born to mothers with anti-HBs titres less than 50 mlU/mL. Despite the mother’s anti-HBs-positive status, our data show a good immunogenicity of the Brazilian HBV recombinant vaccine in neonates.engAcesso AbertoHepatitis B vaccineNewborn infantsAntibody responseArtigo10.1590/S0074-02762011000100018