2024-03-082024-03-082018LIMA, Rita de Cássia Lemos et al. Brazilian insulin plant as a bifunctional food: dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antidiabetic compounds in Myrcia rubella Cambess. Journal of Functional Foods, Amsterdam, v. 45, p. 444-451, 2018. DOI: 10.1016/j.jff.2018.04.019. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1756464618301580?via%3Dihub. Acesso em: 7 mar. 2024.1756-4646e- 2214-9414https://www.sciencedirect.com/science/article/abs/pii/S1756464618301580?via%3DihubSix species of Myrcia, commonly known as 'insulin plants' in Brazil, were assessed for their potential as functional foods. Thus, dual high-resolution α-glucosidase/PTP1B inhibition profiling and HPLC-HRMS-SPE-NMR analysis were used to identify the antidiabetic constituents of the crude ethyl acetate extract of M. rubella Cambess. A total of 31 compounds were identified, including seven α-glucosidase inhibitors with IC50 values between 0.6 and 22.4 μM: 4,5-dicaffeoylquinic acid, isoquercitrin, quercetin-3-O-β-d-glucuronide, kaempferol-3-O-(6″-galloyl)-β-d-glucopyranoside, quercetin-3-O-(6″-malonyl)-glucopyranoside, quercetin-3-O-(6″-(E)-feruloyl)-β-d-glucopyranoside, and quercetin-3-O-(2″-(E)-sinapoyl)-glucopyranoside as well as three strong PTP1B inhibitors with IC50 values between 0.4 and 3.1 μM: kaempferol-3-O-α-l-rhamnoside, astragalin, and arjunolic acid. These results show that M. rubella is a potential bifunctional food for management of type 2 diabetes.engAcesso RestritoArtigo10.1016/j.jff.2018.04.019