2023-05-232023-05-232023-02-09SANTOS, Yanka Machado de Paula. Avaliação do emprego de nanotecnologia à formulações de uso oral de aciclovir. 2023. 17 f. Trabalho de Conclusão de Curso (Bacharelado em Farmácia) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2023.http://repositorio.bc.ufg.br/handle/ri/22605Acyclovir is an antiviral from the class of nucleoside analogues, which has selective action against Herpes Simplex virus types 1 and 2 (HSV 1 and HSV2) and against Varicella-Zoster virus (VZV), being chosen as the gold standard for treatment of these pathologies. Is used to treat primary herpes by reducing the duration of symptoms, but its low oral absorption resulting from low solubility and permeability implies the frequent use of high doses, which increases the chances of adverse effects and reduces adherence to treatment. Due to the potential characteristics of nanometric systems, this approach has been studied as a strategy for delivering, improving solubility and sustained release of Acyclovir. In view of this, this work aimed to evaluate the use of nanotechnology as a strategy to improve the oral bioavailability of the drug Acyclovir, through a bibliographic survey. A limited number of works were found when it comes to improving oral bioavailability, but the reported nanometric systems proved to be promising, such as the use of polymeric nanoparticles, mucoadhesive polymers, solid lipid nanoparticles, nanoemulsions and the association of different techniques such as the use of nanocrystals. Therefore, nanotechnology has demonstrated results that can help to offer a more effective treatment for the oral use of acyclovir.porAcesso AbertoAciclovirNanotecnologiaBiodisponibilidade oralSolubilidadeAcyclovirNanotechnologyOral bioavailabilitySolubilityTCC