2020-01-282020-01-282005-03CONCEIÇÃO, Edemilson Cardoso da; MACHADO, Alexandre Alves; IZUMI, Clarice; FREITAS, Osvaldo de. Calcium carbonate reduces iron absorption from iron sulfate, but not when iron is presented as an organic complex. Alimentos e Nutrição, Araraquara, v. 16, p. 1-4, Jan./Mar. 2005.0103-4235e- 2179-4448http://repositorio.bc.ufg.br/handle/ri/18580Experimental and epidemiological evidences have demonstrated that calcium inhibits iron absorption; calcium carbonate being one of the most effective calcium sources to reduce iron absorption from dietary origin or from iron sulfate. In the present work, the short-term effect of calcium from calcium carbonate on iron absorption was studied in rats, using different iron compounds (monosodium ferric EDTA, iron-bysglicine, iron peptide complex) with iron sulfate as a control. Eighty (80) animals were divided into groups of 10 animals each with homogeneous weight. After 18h fast, the animals received by gavage 5 mL of a dispersion containing one of the iron compounds (1mg Fe/kg body weight), concomitantly or not with calcium carbonate at a molar ratio of 150:1 (Ca/Fe). Two hours after the administration, the animals were sacrificed and blood was collected for serum iron determination (iron transfer rate from intestinal lumen to blood compartment). Additionally, the intestines were collected for soluble iron determination (available iron). The results demonstrated that calcium ion from calcium carbonate inhibits the iron absorption from iron sulfate, but not from organic iron (di- or trivalent) complexes.engAcesso AbertoIron absorptionIron complexesCalciumAbsorção de ferroFerro complexadoCálcioArtigo