2018-07-102018-07-102014FREITAS, Carla S. de; KATO, Lucilia; OLIVEIRA, Cecília M. A. de; QUEIROZ JR, Luiz H. K; SANTANA, Mábio J.; SCHUQUEL, Ivânia T.; DELPRETE, Piero G.; SILVA, Roosevelt A. da; QUINTINO, Guilherme O.; SILVA NETO, Benedito R. da; SOARES, Célia M. A.; PEREIRA, Maristela. β-carboline alkaloids from galianthe ramosa inhibit malate synthase from Paracoccidioides spp.. Planta Medica, Stuggart, v. 80, n. 18, p. 1746-1752, 2014.0032-0943e- 1439-0221http://repositorio.bc.ufg.br/handle/ri/15373As part of our continuing chemical and biological analyses of Rubiaceae species from Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin, ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase from the pathogenic fungus Paracoccidioides spp. This enzyme is con- sidered an important molecular target because it is not found in humans. Molecular docking simu- lations were used to describe the interactions be- tween the alkaloids and malate synthase.engAcesso AbertoArtigo10.1055/s-0034-1383305