2023-07-032023-07-032016SANTOS, Pâmella F. dos et al. 2-(4-iodo-2,5-dimetoxifenil)-N-[(2-metoxifenil)metil]etamina ou 25I-NBOMe: caracterização química de uma designer drug. Química Nova, São Paulo, v. 39, n. 2, p. 229-237, 2016. DOI: 10.5935/0100-4042.20150178. Disponível em: https://quimicanova.sbq.org.br/detalhe_artigo.asp?id=6352. Acesso em: 21 jun. 2023.e- 1678-70640100-4042http://repositorio.bc.ufg.br/handle/ri/22871Drug trafficking and the introduction of new drugs onto the illicit market are one of the main challenges of the forensic community. In this study, the chemical profile of a new designer drug, 2-(4-iodine-2,5- dimethoxyphenyl)-n-[(2-methoxyphenyl)methyl]etamine or 25I-NBOMe was explored using thin layer chromatography (TLC), ultraviolet-visible spectrophotometry (UV-Vis), attenuated total reflection with Fourier transform infrared spectroscopy(ATRFTIR), gas chromatography mass spectrometry (GC-MS) and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FT-ICR MS). First, the TLC technique was effective for identifying spots related to 25C-, 25B- and 25I-NBOMe compounds, all with the same retention factor, Rf ≈ 0.50. No spot was detected for 2,5-dimethoxy-4-bromoamphetamine, 2,5-Dimethoxy-4-chloroamphetamine or lysergic acid diethylamide compounds. ATR-FTIR preserved the physical-chemical properties of the material, whereas GC-MS and ESI-MS showed better analytical selectivity. ESI(+)FT-ICR MS was used to identify the exact mass (m/z 428.1706 for the [M + H]+ ion), molecular formula (M = C18H22INO3), degree of unsaturation (DBE = 8) and the chemical structure (from collision induced dissociation, CID, experiments) of the 25I-NBOMe compound. Furthermore, the ATR-FTIR and CID results suggested the presence of isomers, where a second structure is proposed as an isomer of the 25I-NBOMe molecule.porAcesso AbertoDesigner drugs25I-NBOMeCCDATR-FTIRGC-MSESI(+)-FT-ICR MSArtigo10.5935/0100-4042.20150178