2019-11-062019-11-062008-07FREITAS-JÚNIOR, Ruffo de et al. Estudo experimental comparando o uso do 2-octil cianoAcrilato ao nylon 4-0 na sutura da pele. Revista do Colégio Brasileiro de Cirurgiões, Rio de Janeiro, v. 35, n. 3, p. 194-198, 2008.0100-6991e- 1809-4546http://repositorio.bc.ufg.br/handle/ri/18326Background: Tissue adhesive 2-octyl cyanoacrylate was developed to have more strength, less inflammatory reaction, and less histotoxicity than its shorter-chain derivates. Methods: To evaluate the use of 2-octil cyanoacrylate in comparison with “nylon” suture in skin closure of rats. Methods: Twenty-five female Wistar rats were submitted to a 3cm surgical incision in each side of the abdomen. The wound was closed with intradermic suture using “nylon” 4-0 in one side, and 2-octil cyanoacrylate on the other side. After 7 days the thread was removed and the wound was checked for complications. After 40 days the wound aspect was clinically evaluated. The rats were sacrificed; the scars were resected, and sent to the pathologist without the information of which closing method was used. Results: There were 2 deaths during anesthesia or few days after surgery. The mean surgical time was 136 seconds with the adhesive and 176 with “nylon” (P=0.003). The complications were: one hematoma in each method (P=0.8), fifteen wound dehiscence with the adhesive and 11 with “nylon” (P=0.2), seven scars with a bad or fair aspect with adhesive and 4 with “nylon” (P=0.3), three infections with adhesive and 2 with “nylon” 2 (P=0.4). Histological examination showed median scar width of 1.119 micron with the adhesive and 1.800 with “nylon” (P=0.7). The mean thickness was 1.795 in the adhesive group versus 1.705 micron (P=0.7). Conclusion: Surgical adhesive showed the same aesthetical results, the same strength, and the same complications as for “nylon” 4.0 sutures, but the adhesive decreased the surgical time.porAcesso AbertoTécnicas de suturaRatos, modelo experimentalPeleCianoacrilatos/uso terapêuticoNylonsSuture techniquesSkinCyanoacrylates/therapeutic useNylonsRats, experimental modelArtigo10.1590/S0100-69912008000300011