2020-02-142020-02-142013OLIVEIRA-NETO, Helenisa Helena et al. The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis. Tumor Biology, New York, v. 34, n. 1, p. 65-70, 2013.1010-4283http://repositorio.bc.ufg.br/handle/ri/18686The purpose of this study is to determine the expression of CCL19, CCL21, and CCR7 in samples of oral squamous cell carcinoma (OSCC) and their relationship with clinical and microscopic parameters. A comparative analysis was made of the mRNA expression of these chemokines and receptor in OSCC and normal oral mucosa. The immunoexpression of CCR7, CCL19, and CCL21 was also verified in OSCC and lymph nodes. Statistical significance was accepted at P<0.05. Similar levels of CCR7, CCL19, and CCL21 mRNA in OSCC and normal oral mucosa were seen. A low expression of CCL19 and CCL21 in the intraand peritumoral regions was observed. Scarce CCL19+ and CCL21+ cells were also noted in metastatic and nonmetastatic lymph nodes. No association was found between the expression of these chemokines and clinical and microscopic parameters. Our findings would suggest that CCL19 and CCL21 may not be associated with cervical lymph node metastasis or other clinical and microscopic factors in OSCC.engAcesso AbertoCCL19Lymph nodeCCL21MetastasisCCR7Oral squamous cell carcinomaChemokineArtigo10.1007/s13277-012-0511-3