2018-08-242018-08-242007-12COSTA, Elson A, et al. Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks. Revista Brasileira de Farmacognosia, Curitiba, v. 17, n. 4, p. 508-513, Oct./Dec. 2007.0102-695Xe- 1981-528Xhttp://repositorio.bc.ufg.br/handle/ri/15737Cheiloclinium cognatum (Hippocrateaceae) has been used in folk medicine to treat fever and edema. In this paper, we report the anti-infl ammatory and analgesic activities of the crude dichloromethane extract (DECc) from C. cognatum root barks collected in Auguste de Saint Hilaire wood at Universidade Federal de Goiás. Doses of 0.1, 0.3 and 1.0 g/kg caused a dose-dependent inhibition of croton oil-induced ear edema in mice equivalent to 21, 30 and 51%, respectively. There was a signifi cant increase in analgesic-meter-induced tail fl ick test equivalent to 105, 189 and 200% of increase tail fl ick reaction time. These results allowed to suggest that C. cognatum could be a source of new compounds which anti-infl ammatory and analgesic activities.engAcesso AbertoCheiloclinium cognatumHippocrateaceaeEfeito antiinfl amatórioAtividade analgésicaEdema de orelhaPeritoniteAnti-infl ammatory effectAnalgesic activityEar edemaPeritonitisArtigo