2020-01-272020-01-272013OLIVEIRA JR., Francisco V. de; SOUZA, Weimar Sebba Barroso. Análise de eficácia, eventos adversos e desfechos cardiovasculares em estudos relacionados às combinações de nifedipino GITS ou anlodipino com medicamentos que atuam no sistema renina angiotensina aldosterona. Revista Brasileira de Hipertensão, Rio de Janeiro, v. 20, n. 1, p. 34-41, 2013.1519-7522http://repositorio.bc.ufg.br/handle/ri/18565We reviewed 17 studies in order to evaluate the antihypertensive efficacy on the combination of calcium antagonists and angiotensin receptor blockers in lowering the blood pressure, cardiovascular outcomes and incidence of side effects. The combination therapy of amlodipine or nifedipine GITS calcium channel blockers, and angiotensin II receptor blocker valsartan showed, in most studies, more effective than monotherapy to lower blood pressure, as well as more beneficial to decrease cardiovascular events. The safety profile and tolerability of the combinations also proved quite acceptable, with side effects management benefited by higher possibility of adjustments on doses of substances with different mechanisms of actions, without affecting the antihypertensive efficacy.porAcesso AbertoNifedipino GITSEfeitos adversosAnolodipinoEventos cardiovascularesValsartanaNifedipine GITSAmlodipineAdverse effectsValsartanCardiovascular eventsHypertensionArtigo