2018-12-212018-12-212005-06FAGUNDES, Flávio A.; OLIVEIRA, Leonardo B. de; CUNHA, Luiz Carlos; VALADARES, Marize Campos. Annona coriacea induz efeito genotóxico em Camundongos. Revista Eletrônica de Farmácia, Goiânia, v. 2, n. 1, p. 24-29, jan./jun. 2005. Disponível em: <https://www.revistas.ufg.br/REF/article/view/1944/1877>.e- 1808-0804http://repositorio.bc.ufg.br/handle/ri/16635This study was designed to evaluate the genetic toxicity of the Annona coriacea using the bone marrow erythrocyte micronucleus test. The results demonstrated that the seed alcoholic extract of this plant, in different doses used (50, 100, 200 or 400mg/kg) induced a significant increase in micronucleus frequencies in bone marrow erythrocytes of mice, when compared to the negative control. In addition, this increase was similar to those found in the group of mice exposed to the positive control (cyclophosphamide 250mg/kg). These results suggest that this plant, in this experimental condition, has a significant potential for induce DNA damage.porAcesso AbertoToxicologia genéticaMicronúcleoAraticumAnnona coriaceaGenetic toxicologyMicronucleiArtigo10.5216/ref.v2i1.1944