2022-01-202022-01-202008HADLER, Maria Claret Costa Monteiro et al. Treament and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiânia, Goiás State, Brazil: a randomized controlled trial. Cadernos de Saúde Pública, Rio de Janeiro, v. 24, supl. 2, p. S259-S271, 2008.e- 1678-44640102-311Xhttp://repositorio.bc.ufg.br/handle/ri/20197The objective of this study was to assess the prevalence of anemia and the therapeutic and prophylactic response to ferrous sulfate and fo lic acid. A double-blind, randomized, controlled clinical trial was conducted with 196 children 6 to 24 months of age enrolled in municipal day care centers in Goiânia, Goiás State, Brazil. The children were assigned to two treatment groups that received a daily dose (5 times a week) of ei ther 4.2mg/kg/day of ferrous sulfate + folic acid (50µg) or 4.2mg/kg/day of ferrous sulfate + fo lic acid placebo. One of the prevention groups received 1.4mg/kg/day of ferrous sulfate + folic acid (50µg/day) and the other 1.4mg/kg/day of ferrous sulfate + folic acid placebo. Supplemen tation lasted approximately three months. Base line anemia prevalence was 56.1% (95%CI: 48.9- 63.1). After treatment, anemia prevalence in the folic acid group (14%) was lower than in the placebo group (34.9%) (p = 0.02). After prophy laxis in the non-anemic children, the incidence of anemia did not differ between the groups, but there was an increase in hemoglobin level in the folic acid group (p = 0.003). Iron plus folic acid was effective for the treatment of anemia and improvement of hemoglobin level in non-ane mic children.porAcesso AbertoNutritional epidemiologyChild day care centersAnemiaFerrous sulfateFolic acidArtigo10.1590/S0102-311X2008001400011