2018-09-062018-09-062012-02BARBOSA, Daniela B. M. e al. Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá). Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, p. 137-143, Jan./Feb. 2012.0102-695Xe- 1981-528Xhttp://repositorio.bc.ufg.br/handle/ri/15864Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A 2 activity assay were used to study the analgesic and/or anti- inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr 10-28 ). HMF and sub-Fr 10-28 reduced the leukocyte migration on the carrageenan- induced pleurisy test; sub-Fr 10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr 10-28 inhibited the phospholipase A 2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A 2 activity.engAcesso AbertoAnti-inflammatoryAntinociceptiveMedicinal plantPhospholipase A 2Spiranthera odoratissimaArtigo10.1590/S0102-695X2011005000154