2024-03-052024-03-052023-08-09SILVA, Marcela Amorim da. Estratégias para melhora da biodisponibilidade oral da insulina: uma descrição dos desafios e das abordagens descritas na literatura. 2023. 22 f. Trabalho de Conclusão de Curso (Bacharelado em Farmácia) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2023.http://repositorio.bc.ufg.br//handle/ri/24469Diabetes Mellitus is a metabolism syndrome characterized by a permanent increase in plasma glucose. Conventional treatment, in addition to being painful and uncomfortable, generates psychological stress due to subcutaneous perforation, which may cause side effects of hyperinsulinemia, weight gain and risks of hypoglycemia. About 45-60% of patients abandon conventional treatment due to needle phobia, and oral insulin can minimize these statistics. The main challenges of oral insulin administration are maintaining the integrity of the peptide throughout the gastrointestinal tract, effecting absorption and increasing sufficient bioavailability for its therapeutic effect. Biopharmaceutical strategies can be employed, among which are: delivery systems, enzyme inhibitors, absorption enhancers, mucoadhesive systems and chemical modifications. Some of the strategies demonstrated a significant increase in bioavailability, as well as in structure protection and increased stability, resulting in promising approaches.porAcesso AbertoDiabetes MellitusSistemas de liberação da insulinaAdministração oral de peptídeosEstratégias tecnológicasInsulin delivery systemsOral administration of peptidesTechnological strategiesTrabalho de conclusão de curso de graduação (TCCG)