2024-02-272024-02-272023-07-28NASCIMENTO, Letícia Alves. Presença de antibióticos na água e seus efeitos tóxicos sobre os ecossistemas e a saúde humana. 2023. 47 f. Trabalho de Conclusão de Curso (Graduação) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2023.http://repositorio.bc.ufg.br//handle/ri/24420Medicines are developed for therapeutic purposes, but the presence of these compounds in the environment has led them to be considered emerging contaminants due to their toxicity to biota. Antibiotics have been found in various water matrices in several countries. In view of this, the aim of this study was to analyze the presence of antibiotics in water resources and their toxic effects on aquatic biota and humans. To this end, a bibliographic search was carried out using the main PUBMED, MEDLINE and GOOGLE ACADEMIC databases. The descriptors used were: antibiotics and wastewater, antibiotics and water and human toxicity, antibiotics and water sources and toxicity, antibiotics in wastewater or aquatic toxicity. A total of 150 articles were found, 134 of which were excluded as only 19 met the inclusion criteria, i.e. articles presenting data on the toxicity of antibiotics present in water resources. In terms of geographical distribution, China and Europe accounted for 31.6% of the publications on this subject. It has been observed that antibiotics are present in the most diverse water matrices: lakes, wastewater, groundwater and even drinking water. Among the main classes of antibiotics found in water resources are fluoroquinolones and sulfonamides. Malformations in aquatic organisms and the selection of resistant bacteria were the main effects observed in relation to the presence of antibiotics in water. The results of this review also indicated that the detection and quantification of these compounds in water resources depends on very sensitive analytical methods, since antibiotics are present in low concentrations. Therefore, it can be concluded that the presence of antibiotics in aquatic resources constitutes a serious public and environmental health problem and that preventive and corrective actions are necessary to minimize this source of exposure and generate subsidies for the establishment of exposure limits to these compounds in water resources.porAcesso AbertoRecursos hídricosAntimicrobianosSaúde únicaToxicidadeWater resourcesAntimicrobialsOne healthToxicityTrabalho de conclusão de curso de graduação (TCCG)