Importância do teste de avidez IGG na toxoplasmose congênita
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Data
2016-03-30
Título da Revista
ISSN da Revista
Título de Volume
Editor
Ruy de Souza Lino Junior
Resumo
The purpose of this study was to evaluate the predictive value of IgG avidity test in the early
diagnosis of congenital toxoplasmosis (CT) in newborns (NB). The study group consisted of 68
pairs of mothers and their newborns, 43 with acute toxoplasmosis during pregnancy and 25 with
negative IgM to Toxoplasma gondii (control group). Patients gave birth in the Maternity Hospital of the Federal University of Goias. We evaluated serum levels of IgM and IgG anti T. gondii, and
avidity IgG. The newborns in the study group were divided into newborns with low avidity (LA)
and newborns with high avidity (HA). Concordance of avidity test was verified between the NB
and mothers. Infection with T. gondii was observed in 94.1% of newborns with LA and 42.3% of
newborns with HA. The levels of IgG and IgM of newborns with LA and their infected mothers
were high and showed differences when compared with the not infected newborns (p=0.0001)
and their mothers. The symptoms of CT were observed in 56% of the newborns with LA and
18% of the newborns with HA. Our data show that newborns with LA present increased levels
of IgM and IgG, and severe symptoms of CT. Thus the avidity test could be used in conjunction
with the detection of IgM and IgG for the early diagnosis of TC in NB.
Descrição
v. 45, n. 1, p. 42-54, jan./mar. 2016.
Palavras-chave
Toxoplasmose congênita, Imunoglobulina G, Diagnóstico, Congenital toxoplasmosis, Immmunoglobulin G, Diagnosis
Citação
FONSECA, Zulmirene Cardoso; RODRIGUES, Isolina Maria Xavier; MELO, Natália Cruz e; CASTRO, Ana Maria; AVELINO, Mariza Martins. Importância do teste de avidez IGG na toxoplasmose congênita. Revista de Patologia Tropical, Goiânia, v. 45, n. 1, p. 42-54, jan./mar. 2016. Disponível em: < http://revistas.ufg.emnuvens.com.br/iptsp/article/view/40078/20576>.