Revisão dataxonomia e classificação do Trypanosoma cruzi - importância da genética
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Data
1986-04
Autores
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Ruy de Souza Lino Junior
Resumo
After the intraspecific variation of
T. cruzi hás been recognized several autnprs
tried to show its correlation with
epidemiology, diagnoses and clinical forms of Chagas' disease in endemic
áreas
Recents advances in the field of
Biochemistry and Immunology brought a
great contribution for the characterization
of isolated stocks of T. cruzi and only
a multidisciplinary study of biológica!,
antigenic and biochemical behaviour of
the parasite would make it possible to solve
taxonomic and classífication problems
of T. cruzi and their clinicai-epidemiologjcal
implications in Chagas' disease.
Since the discovery of the disease
by C. Chagas several authors tried to obtain
chriteria for differentiate the parasite
as the morphological and biological chriteria,
isoenzymic patterns and kDNA
characterization.
Some conclusions from this studies
have been done: l - A particular strain
type may predominate in a particular
geographical área; 2 - Strains of different
types show different antigenic composition;
3 - There is a correlation between
drug sensibility and Strain type; 4 -
Strains of the same type have similares
isoenzymic patherns; 5 - the difíerences
in the strain types are more important in
dctcrmining the course of infection than
the genetic background of the host.
In relation with the antigenic composition
results indicate that: l - There is
intraspecific heterogeneity in original
samplc and in cloned populations; 2 -
This heterogeneity includes parasite oblaincd
from patients, mammals and vectors;
3 It happens with epimastigotes
and trypomastigotes.
The molecular analysis of compoiicnls
mui metabolic products of parasite as lectin binding, isoenzyme patterns and
schizodeme analysis have had a great improvement
in the last decade. Even with
technical limitations, ít can be concluded
from this studies that: l - There seems to
be correlation between zymodeme and
epidemiologica! type of cicie; 2 - A correlation
between cloned sample and lectins
have been shown; 3 - Ali there
zymodemes (Zl, Z2 e Z3) can infected
human beings and cause acute disease,
but it is unfrequent with Z3;4 - Heterozygous
patterns are common in South
America suggesting that T. cruzi may be
diploid. There is no evidence of gene interchange
between zymodemes; 5 - There
is a clear association between the expression
of a surface glycoprotein (GP
72000 kd) and Zl.
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OLIVEIRA, Ana Maria de. Revisão dataxonomia e classificação do Trypanosoma cruzi - importância da genética. Revista de Patologia Tropical, Goiânia, v. 15, n.1, p. 13- 26, jan./abr. 1986. Disponível em: < https://www.revistas.ufg.br/iptsp/article/view/21248/12464>.