Intoxicação de ovinos que receberam duas aplicações de closantel, na dosagem terapêutica (7,5mg/kg), com intervalo de 28 dias
Carregando...
Data
2010-12
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
This study reports poisoning in sheep wich have received two applications of closantel
in therapeutic dosage (7.5mg/kg) within a preestablished 28-day period for effectiveness
formulation. A high percentage of efficiency was observed after the first and second treatment,
but around 72 hours after the second administration of closantel (D30), three sheep
have showed mild apathy, anorexia, diarrhea, bilateral blindness, and dilated pupils without
reaction. These three animals, were observed in the following 250 days, and the bilateral
blindness remained. Numerous reports of animals poisoned by closantel emphasize that
overdose and/or nutritional status of the animals are key factors to occur poisoning due
closantel administration. However, in this experiment the signs of poisoning (mild apathy,
anorexia, diarrhea and ophthalmic disturbance), observed in the three clinically healthy
sheep, occurred when they received two applications of closantel (7.5mg/kg), in a interval
of 28 days, highlighting the fact of obtaining a cumulative residual effect of closantel in the
animal organism, caused by two consecutive applications, may also be a predisposing factor
for sheep to demonstrate irreversible signs of intoxication.
Descrição
Palavras-chave
Closantel, Eficácia, Intoxicação, Ovino, Retina, Closantel, Efficacy, Poisoning, Sheep, Retina
Citação
LOPES, Welber Daniel Zanetti; CARVALHO, Rafael Silveira; OLIVEIRA, Pedro Victor; PEREIRA, Valdomiro; MARTINEZ, Antônio Campanha; MAZZUCATTO, Barbara Cristina; COLLI, Marcos Henrique Alcântara; RUIVO, Maycon Araújo. Intoxicação de ovinos que receberam duas aplicações de closantel, na dosagem terapêutica (7,5mg/kg), com intervalo de 28 dias. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 34, n. 12, p. 1162-1166, 2014.