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Tipo do documento: Artigo
Título: Identification of the GTPase superfamily in Mycoplasma synoviae and Mycoplasma hyopneumoniae
Autor: Borges, Clayton Luiz
Rocha, Juliana Alves Parente
Pereira, Maristela
Soares, Célia Maria de Almeida
Abstract: Mycoplasmas are the smallest known prokaryotes with self-replication ability. They are obligate parasites, taking up many molecules of their hosts and acting as pathogens in men, animals, birds and plants. Mycoplasma hyopneumoniae is the infective agent of swine mycoplasmosis and Mycoplasma synoviae is responsible for subclinical upper respiratory infections that may result in airsacculitis and synovitis in chickens and turkeys. These highly infectious organisms present a worldwide distribution and are responsible for major economic problems. Pro- teins of the GTPase superfamily occur in all domains of life, regulating functions such as protein synthesis, cell cycle and differentiation. Despite their functional diversity, all GTPases are believed to have evolved from a single com- mon ancestor. In this work we have identified mycoplasma GTPases by searching the complete genome databases of Mycoplasma synoviae and Mycoplasma hyopneumoniae, J (non-pathogenic) and 7448 (pathogenic) strains. Fif- teen ORFs encoding predicted GTPases were found in M. synoviae and in the two strains of M. hyopneumoniae. Searches for conserved G domains in GTPases were performed and the sequences were classified into families. The GTPase phylogenetic analysis showed that the subfamilies were well resolved into clades. The presence of GTPases in the three strains suggests the importance of GTPases in `minimalist’ genomes.
Palavras-chave: Mycoplasma
GTPase superfamily
País: Brasil
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: BORGES, Clayton Luiz; PARENTE, Juliana Alves; PEREIRA, Maristela; SOARES, Célia Maria de Almeida. Identification of the GTPAse superfamily in Mycoplasma synoviae and Mycoplasma hyopneumoniae. Genetics and Molecular Biology, Ribeirão Preto, v. 30, n. 1, supl., p. 212-218, 2007.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S1415-47572007000200007
Identificador do documento: 10.1590/S1415-47572007000200007
Data de publicação: 2007
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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