Pesquisa de IgA contra o antígeno recombinante HspX de Mycobacterium tuberculosis no diagnóstico de tuberculose pleural
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Data
2011
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Resumo
Objective: To evaluate the accuracy of determining specific IgA to HspX recombinant antigen in pleural fluid
and serum samples for the diagnosis of pleural tuberculosis in patients with pleural effusion. Methods: This
was a cross-sectional study. Serum and pleural fluid samples of patients with pleural effusion and suspected of
having pleural tuberculosis were tested with indirect ELISA in order to determine the optical density of specific
IgA to HspX. Results: We evaluated serum and pleural fluid samples from 132 patients: 97 diagnosed with
pleural tuberculosis (study group) and 35 diagnosed with pleural effusion due to other causes (control group).
The determination of IgA in pleural fluid satisfactorily discriminated between pleural tuberculosis patients and
control patients. The sensitivity of the test in pleural fluid and in serum was 69% and 30%, respectively, whereas
the specificity was 83% and 84%, respectively. Conclusions: Our data suggest that this test can be used in the
diagnosis of pleural tuberculosis. Further studies, involving larger patient samples and different epidemiological
scenarios, are warranted.
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Palavras-chave
ELISA, Derrame pleural, Tuberculose diagnóstico, Enzyme-linked immunosorbent assay, Pleural effusion, Tuberculosis
Citação
LIMONGI, Loanda Carvalho Sant’ Ana et. al. Pesquisa de IgA contra o antígeno recombinante HspX de Mycobacterium tuberculosis no diagnóstico de tuberculose pleural. Jornal Brasileiro de Pneumologia, Brasília, v. 37, n. 3, p. 302-307, 2011.