Characterization of Cryptococcus neformans isolated from urban environmental sources in Goiania, state Goias, Brazil
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Data
2005-08
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Resumo
Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis as the most frequent clinical
presentation in immunocompromised patients, mainly in people infected by HIV. This fungus is an environmental encapsulated
yeast, commonly found in soil enriched with avian droppings and plant material. A total of 290 samples of pigeon and the other
avian droppings, soil, ornamental trees and vegetable material associated with Eucalyptus trees were collected to study environmental
sources of Cryptococcus species in Goiânia, Goiás State. The determination of varieties, serotypes and the susceptibility in vitro
to fluconazole, itraconazole and amphotericin B of C. neoformans isolates were performed. C. neoformans var. grubii (serotype
A) was found in 20.3% (36/177) of pigeon dropping samples and in 14.3% (5/35) of samples of Eucalyptus. None of the environmental
isolates of C. neoformans showed in vitro resistance to three antifungal agents. The knowledge of major route for human cryptococcal
infection (inhalation of infectious particles from saprophytic sources) and a total of 60 C. neoformans isolates obtained from
AIDS patients with cryptococcal meningitis between October 2001 and April 2002 justify the study of the habitats of these yeasts
as probable sources of cryptococcosis in this city.
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Cryptococcus neoformans, Susceptibility testing, Environmental isolates, Pigeon droppings
Citação
SILVA, Maria do Rosário Rodrigues. Characterization of Cryptococcus neformans isolated from urban environmental sources in Goiania, state Goias, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 47, n. 4, July/Aug. 2005.