Experimental encephalitis caused by Taenia crassiceps cysticerci in mice
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Data
2012
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Resumo
Objectives: To present the experimental model of neurocysticercosis (NCC) caused by Taenia crassiceps cysticerci, to describe the inflam-
matory process, susceptibility, or resistance of BALB/c and C57BL/6 mice to this infection, and to describe the host-parasite relationship.
Methods: The animals were intracranially inoculated with initial stage T. crassiceps cysticerci. They were euthanized at 7, 30, 60, and 90 days
after the inoculation. Their encephala were removed for the histopathologic analysis, classification of the parasites, and inflammatory le-
sions. Results: Experimental NCC was observed on both mice lineages. BALB/c mice presented inflammatory lesions with greater intensity,
inducing necrosis on late stage parasites, and with an acute inflammation pattern, while C57BL/6 mice showed greater capability on pro-
voking early necrosis in the cysticerci, which showed a chronic inflammation pattern. Conclusions: This experimental model induced NCC
on mice with characteristic inflammation and lesions. C57BL/6 mice were able to induce precocious necrosis of the parasites presenting
inflammatory lesions with lower intensity.
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Neurocysticercosis, C57BL/6, Taenia crassiceps, BALB/c
Citação
MATOS-SILVA, Hidelberto; RECIPUTTI, Bruno Pereira; PAULA, Élbio Cândido de; Oliveira, André Luiz; MOURA, Beatriz Lopes; VINAUD, Marina Clare; OLIVEIRA, Milton Adriano Pelli; LINO-JUNIOR, Ruy de Souza. Experimental encephalitis caused by Taenia crassiceps cysticerci in BALB/c and C57BL6 mice. Arquivos de Neuro-Psiquiatria, São Paulo, v. 70, n. 4, p. 287-294, Feb. 2012.