In vitro susceptibility testing of dermatophytes isolated in Goiania, Brazil against five antifungal agents by broth microdilution method
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Data
2009-02
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Resumo
The antifungal activities of fluconazole, itraconazole, ketoconazole, terbinafine and griseofulvin were tested by broth microdilution
technique, against 60 dermatophytes isolated from nail or skin specimens from Goiania city patients, Brazil. In this study, the microtiter
plates were incubated at 28 o C allowing a reading of the minimal inhibitory concentration (MIC) after four days of incubation for
Trichophyton mentagrophytes and five days for T. rubrum and Microsporum canis. Most of the dermatophytes had uniform patterns
of susceptibility to the antifungal agents tested. Low MIC values as 0.03 μg/mL were found for 33.3%, 31.6% and 15% of isolates
for itraconazole, ketoconazole and terbinafine, respectively.
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Dermatophytes, Minimal inhibitory concentration, Broth microdilution method
Citação
ARAÚJO, Crystiane Rodrigues; MIRANDA, Karla Carvalho ; FERNANDES, Orionalda de Fatima Lisboa; SOARES, Ailton José; SILVA, Maria do Rosario Rodrigues. In vitro susceptibility testing of dermatophytes isolated in Goiania, Brazil against five antifungal agents by broth microdilution method. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 51, n. 1, p. 9-12, Jan./Feb. 2009.