Lagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of H-2a haplotype and correlates with the immune response in immunized animals
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2010
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Recently, we demonstrated that C57BL/6 mice are more susceptible to experimental lagochilascariosis than BALB/c mice. To
investigate the pattern of infection and the role of the genetic background on susceptibility to infection, we studied experimental
lagochilascariosis in H-2 a identical B10.A and A/J mice. Infected B10.A mice had a lower survival ratio and more severe lesions
in the lungs than did A/J mice. Splenocytes of A/J mice immunized with the crude extract of the parasite showed increased
proliferation and produced a higher level of interleukin 10 and interferon-γ in the presence of CE or concanavalin A when
compared to B10.A mice. This suggests that resistance of A/J mice may be due to less severe lesions in lungs and other organs and a
better immune response to parasite antigens. This paper provides evidence that major histocompatibility complex haplotype does
not influence the survival to experimental infection with L. minor.
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SPADAFORA-FERREIRA, Mônica; FERNANDES, Luciana Caetano; PFRIMER, Irmtraut Araci Hoffman; PICHITELI, Cássia Regina; TAMBOURGI, Denise Vilarinho; LINO-JUNIOR, Ruy de Souza; CARVALHAES, Mara Silvia. Lagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of H-2a haplotype and correlates with the immune response in immunized animals. Journal of Parasitology Research, London, v. 2010, p. 1-9, 2010.