Macroscopic placental changes associated with fetal and maternal events in diabetes mellitus
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Data
2012
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Resumo
OBJECTIVES: The current study sought to identify macroscopic placental changes associated with clinical conditions
in women with or without diabetes and their newborns.
METHODS: The study population consisted of 62 pregnant women clinically diagnosed with diabetes and 62 healthy
women (control group).
RESULTS: Among the subjects with diabetes, 43 women (69.3%) were diagnosed with gestational diabetes mellitus,
15 had diabetes mellitus I (24.2%), and four had diabetes mellitus II (6.5%). The mean age of the women studied
was 28.5¡5.71 years, and the mean gestational age of the diabetic women was 38.51 weeks. Of the 62 placentas
from diabetic pregnancies, 49 (79%) maternal surfaces and 59 (95.2%) fetal surfaces showed abnormalities,
including calcium and fibrin deposits, placental infarction, hematoma, and fibrosis. A statistical association was
found between newborn gender and fetal and maternal placental changes (p = 0.002). The mean weight of the
newborns studied was 3,287¡563 g for women with diabetes mellitus, 3,205¡544 g for those with gestational
diabetes mellitus, 3,563¡696 g for those with diabetes mellitus II, and 3,095¡451 g for those with diabetes mellitus I.
CONCLUSIONS: Infarction, hematoma, calcification, and fibrin were found on the maternal and fetal placental
surfaces in women with diabetes. Women with gestational diabetes and post-term infants had more calcium
deposits on the maternal placental surface as compared to those with type I and type II diabetes.
Descrição
Palavras-chave
Diabetes mellitus, Newborn, Placenta, Pregnancy
Citação
SALGE, Ana Karina Marques et al. Macroscopic placental changes associated with fetal and maternal events in diabetes mellitus. Clinics, São Paulo, v. 67, n. 10, p. 1203-1208, 2012.