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dc.creatorFajemiroye, James Oluwagbamigbe-
dc.creatorMartins, José Luís Rodrigues-
dc.creatorGhedini, Paulo César-
dc.creatorCarvalho, Pablinny Moreira Galdino de-
dc.creatorPaula, Joelma Abadia Marciano de-
dc.creatorPaula, José Realino de-
dc.creatorRocha, Fabio Fagundes da-
dc.creatorCosta, Elson Alves-
dc.identifier.citationFAJEMIROYE, James Oluwagbamigbe et al. Antidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymes. Evidence-Based Complementary and Alternative Medicine, London, v. 2013, p. 1-8, 2013.pt_BR
dc.identifier.issne- 1741-4288-
dc.description.abstractPimenta pseudocaryophyllus popularly referred to as craveiro is considered as a calming agent in different local preparations. e present study attempted to examine antidepressant-like effect of dichloromethane fraction (DF) and role of monoamine oxidase (MAO), tryptophan, and tyrosine hydroxylase. Based on the research focus, tail suspension (TS), forced swimming (FS), and open �eld (OF) tests were conducted a�er oral administration of DF (125, 250, or 500 mg/Kg). Ex vivo assay of MAO was also conducted to evaluate inhibitory effect of DF (250 mg/Kg). Administration of DF elicits antidepressant-like response in the TS and FS. However, DF 500 mg/Kg did not alter mice performance in these models. e data obtained in the OF showed a reduction in total crossing and rearing activity; these effects suggest motor interference in TS and FS performance. Mice pretreatment with p-chlorophenylalanine methyl ester (PCPA) (100 mg/kg, i.p.—serotonin biosynthesis inhibitor) for 4 consecutive days or acute administration of αα-methyl-p-tyrosine (AMPT) (100 mg/kg, i.p.—catecholamine synthesis inhibitor) blocked anti-immobility effect of DF in the FS. In ex vivo assay of MAO, DF did not inhibit catabolic activity of MAO. Our �ndings support antidepressant-pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAntidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymespt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
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