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Tipo do documento: Artigo
Título: Antidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymes
Autor: Fajemiroye, James Oluwagbamigbe
Martins, José Luís Rodrigues
Ghedini, Paulo César
Carvalho, Pablinny Moreira Galdino de
Paula, Joelma Abadia Marciano de
Paula, José Realino de
Rocha, Fabio Fagundes da
Costa, Elson Alves
Abstract: Pimenta pseudocaryophyllus popularly referred to as craveiro is considered as a calming agent in different local preparations. e present study attempted to examine antidepressant-like effect of dichloromethane fraction (DF) and role of monoamine oxidase (MAO), tryptophan, and tyrosine hydroxylase. Based on the research focus, tail suspension (TS), forced swimming (FS), and open �eld (OF) tests were conducted a�er oral administration of DF (125, 250, or 500 mg/Kg). Ex vivo assay of MAO was also conducted to evaluate inhibitory effect of DF (250 mg/Kg). Administration of DF elicits antidepressant-like response in the TS and FS. However, DF 500 mg/Kg did not alter mice performance in these models. e data obtained in the OF showed a reduction in total crossing and rearing activity; these effects suggest motor interference in TS and FS performance. Mice pretreatment with p-chlorophenylalanine methyl ester (PCPA) (100 mg/kg, i.p.—serotonin biosynthesis inhibitor) for 4 consecutive days or acute administration of αα-methyl-p-tyrosine (AMPT) (100 mg/kg, i.p.—catecholamine synthesis inhibitor) blocked anti-immobility effect of DF in the FS. In ex vivo assay of MAO, DF did not inhibit catabolic activity of MAO. Our �ndings support antidepressant-
País: Gra-bretanha
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: FAJEMIROYE, James Oluwagbamigbe et al. Antidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymes. Evidence-Based Complementary and Alternative Medicine, London, v. 2013, p. 1-8, 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2013/659391
Identificador do documento: 10.1155/2013/659391
Data de publicação: 2013
Aparece nas coleções:ICB - Artigos publicados em periódicos

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