Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract
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Data
2014
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Resumo
The Celtis iguanaea (Jacq.) Sargent (Cannabaceae) is one of the native species of
the Cerrado region of Brazil widely used in folk medicine to treat dyspepsia. The objective of the
present study was to evaluate the gastroprotective effect of the Celtis iguanaea (Jacq.) Sargent
(HE) hexane leaf extract in the lesion and gastric secretion models.Antiulcerogenic activity of the
Celtis iguanaea (HE) hexane leaf extract was observed with the experimental models, such as
indomethacin and pyloric ligation-induced gastric ulcers. In order to evaluate the antisecretory
activity of this extract, isolated Rana catesbeiana mucosa and pyloric ligation in mice were used.
The HE treatment reduced the lesion index of indomethacin and pyloric ligation-induced ulcer.
This extract also reduced the gastric acid secretion and total acidity (increasing the gastric pH)
in mice. The secretion of H + was reduced in the basal values (15.58 ± 1.99 μEq H + /g/15 min)
when isolated Rana catesbeiana mucosa was incubated with HE. Intraduodenal administration
of HE reduced the gastric secretion produced by bethanecol or histamine. The antiulcerogenic
and antisecretory efficacy of HE in this study suggest anticholinergic and antihistaminergic
mechanism or interruption of intracellular events that are linked to acid secretion.
Descrição
Palavras-chave
Celtis iguanaea, Hexane extract, Antiulcerogenic activity, Cerrado, Antisecretory activity, Extrato hexânico, Atividade anti-ulcerogênica, Atividade antisecretória, Cerrado
Citação
MARTINS, J. L. R. et al. Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract. Revista Brasileira de Plantas Medicinais, Campinas, v. 16, n. 2, p. 250-255, Apr./Jun. 2014.