Spray drying of Eugenia dysenterica extract: effects of in-process parameters on product quality
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Data
2013-02
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Resumo
A 2 3 full factorial design was used to assess the impact of spraying air fl ow
rate (30-50 L/min), drying air inlet temperature (90-150 oC) and extract feed rate (4-6
g/min) on the quality of Eugenia dysenterica DC., Myrtaceae, spray-dried extracts.
Response surface methodology (RSM) was applied to analyze the signifi cance of the
effects of process factors on product quality and to obtain fi tted equations to predict
dry powder properties. Powder yields were satisfactory, ranging from 34.64 to 63.92%.
The dried products showed moisture contents and water activities below 5% and 0.5,
respectively. The recuperation ratios of total polyphenols, tannins and fl avonoids
ranged from 88.66 to 99.07%, 70.38 to 81.87% and 74.51 to 98.68%, respectively.
Additionally, in some conditions the parameters related to dry product’s fl owability
and compressibility varied over a range acceptable for pharmaceutical purposes. RSM
proved that studied factors signifi cantly affected most of the quality indicators at
different levels. The spray drying technology is an attractive and promising alternative
for the development of intermediate phytopharmaceutical products of E. dysenterica.
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Eugenia dysenterica, Phytopharmaceuticals, Response surface methodology, Spray drying
Citação
COUTO, Renê O. et al. Spray drying of Eugenia dysenterica extract: effects of in-process parameters on product quality. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 1, p. 115-123, Jan./Feb. 2013.