Randomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (Field horsetail) in healthy volunteers
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2014
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In this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups (𝑛 = 12)
that underwent a three-step treatment. For four consecutive days, we alternately administered a standardized dried extract of
Equisetum arvense (EADE, 900mg/day), placebo (corn starch, 900mg/day), or hydrochlorothiazide (25mg/day), separated by a
10-day washout period. Each volunteer served as his own control, and the groups’ results were compared. We repeated the same
evaluation after each stage of treatment to evaluate the safety of the drug.The diuretic effect of EADE was assessed by monitoring
the volunteers’ water balance over a 24 h period. The E. arvense extract produced a diuretic effect that was stronger than that of
the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of
electrolytes. There was no significant increase in the urinary elimination of catabolites. Rare minor adverse events were reported.
The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe
for acute use. Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological
actions of this phytomedicine.
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CARNEIRO, Danilo Maciel et al. Randomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (Field horsetail) in healthy volunteers. Evidence-Based Complementary and Alternative Medicine, London, v. 2014, e760683, 2014.