Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice
Carregando...
Data
2013
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862),
popularly known as “sofre-do-rim-quem-quer” and “araticum-seco”,
is a shrub of the Annonaceae family that grows in several regions of
Brazil. Infusions of its leaves and twigs are used in folk medicine to
treat rheumatism and renal colic, whereas the seed powder is mixed with
water to treat pediculosis. Studies on the plant have reported biological
activities with cytotoxic, antitumoral, trypanocidal, leishmanicidal,
antiplasmodial, and antiprotozoal effects. Our previous studies using a
prophage l induction test (SOS-Inductest) and the micronucleus assay
demonstrated that D. furfuracea lyophilized leaf extract (DFE) displayed
cytotoxic but not genotoxic activity. In the present study, antigenotoxic
and anticytotoxic activities of DFE were evaluated using SOS-Inductest
and mouse bone marrow micronucleus tests. Our results showed that DFE
decreased the induction of either prophage l (P < 0.05; SOS-Inductest) or
micronucleated polychromatic erythrocytes (P < 0.05; micronucleus test)
at all doses, suggesting antigenotoxic activity in both tests. On assessing
the anticytotoxic activity of DFE, a significant increase in the number of
bacteria at lower doses (P < 0.05) as well as a significant increase in the
polychromatic and normochromatic erythrocyte ratio were observed (P <0.05), demonstrating the anticytotoxic activity of DFE. Thus, D. furfuracea
displayed antigenotoxic and anticytotoxic activity in both assays.
Descrição
Palavras-chave
Duguetia furfuracea, SOS-inductest, Antigenotoxicity, Micronucleus test, Anticytotoxicity
Citação
SILVA, C. R.; VIEIRA, P. M.; L., Chen-Chen. Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice. Genetics and Molecular Research, Ribeirão Preto, v. 12, n. 3, p. 3718-3725, 2013.