Phospholipase gene expression during Paracoccidioides brasiliensis morphological transition and infection
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Data
2013-09
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Resumo
Phospholipase is an important virulence factor for pathogenic fungi. In this study, we demonstrate the following:
(i) the Paracoccidioides brasiliensis pld gene is preferentially expressed in mycelium cells, (ii) the plb1 gene is mostly
up-regulated by infection after 6 h of co-infection of MH-S cells or during BALB/c mice lung infection, (iii) during
lung infection, plb1, plc and pld gene expression are significantly increased 6-48 h post-infection compared to 56
days after infection, strongly suggesting that phospholipases play a role in the early events of infection, but not dur-
ing the chronic stages of pulmonary infection by P. brasiliensis.
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Host-pathogen interaction, Paracoccidioides brasiliensis, Pathogenicity, Phospholipases
Citação
SOARES, Deyze Alencar et al . Phospholipase gene expression during Paracoccidioides brasiliensis morphological transition and infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 6, p. 808-811, Sept. 2013.