Failure of nitric oxide production by macrophages and decrease in CD4+ T cells in oral paracoccidioidomycosis: possible mechanisms that permit local fungal multiplication
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Data
2005-10
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Resumo
Paracoccidioidomycosis is a chronic granulomatous disease that induces a specific inflammatory and immune response. The
participation of nitric oxide (NO), a product of the inducible nitric oxide synthase enzyme (iNOS), as an important fungicidal
molecule against Paracoccidioides brasiliensis has been demonstrated. In order to further characterize the Oral
Paracoccidioidomycosis (OP), we undertook an immunohistochemical study of iNOS + , CD45RO + , CD3 + , CD8 + , CD20 + , CD68 +
cells and mast cells. The samples were distributed in groups according to the number of viable fungi per mm 2 . Our results showed
weak immunolabeling for iNOS in the multinucleated giant cells (MNGC) and in most of the mononuclear (MN) cells, and the
proportion of iNOS + MN/MNGC cells in the OP were comparable to Control (clinically healthy oral tissues). Additionally, our
analysis revealed a similarity in the number of CD4 + cells between the Control and the OP groups with higher numbers of fungi.
These findings suggest that a low expression of iNOS and a decrease in the CD4 + T cells in OP may represent possible mechanisms
that permit the local fungal multiplication and maintenance of active oral lesions.
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Paracoccidioidomycosis, Immune cells, Nitric oxide
Citação
BATISTA, Aline Carvalho; SOARES, Cleverson Teixeira; LARA, Vanessa SoareS. Failure of nitric oxide production by macrophages and decrease in CD4+ T cells in oral paracoccidioidomycosis: possible mechanisms that permit local fungal multiplication. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 47, n. 5, p. 267-273, Sept./Oct. 2005.