A suplementação de ácido fólico na prevenção de disfunções autonômicas cardíacas e de anomalias do tubo neural: uma revisão sistemática
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Data
2015
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Resumo
Objective: Elaborate a systematic review that discuss the relation between the folate and
congenital heart anomalies and neural tube defects, furthermore the evaluation of autonomic
modulation and heart rate variability (HRV) in mother-child’s health. Methods: The PubMed,
Scopus and SciELO databases were searched for observational studies published between 2009
and 2014 using the terms “Folic acid and cardiac anomalies and human”, “Folic acid and heart
rate and pregnancy”, “Folic acid and cardiac autonomic”, “Folic acid and congenital and neural
tube defects”. Results: There was 520 articles and 16 have been chosen, despise those articles
that were duplicated or because of the exclusion criteria. The systematization of the studies
highlights: i) folic acid and neural tube defects; ii) folic acid and cardiac anomalies and iii) folic
acid and autonomic modulation. Conclusions: This systematic review also shows a preventive
role of folic acid on heart disease and congenital neural tube. Points to a close relationship with
the decrease in homocysteine levels acting in preventing cardiovascular disorders. Experimental
studies are needed to elucidate the effects of folic acid supplementation on the autonomic
dysfunctions heart mothers and neonates.
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Ácido fólico, Cardiopatias congênitas, Frequência cardíaca, Defeitos do tubo neural, Gestantes, Folic acid, Heart rate, Heart defects, congenital, Pregnant women, Neural tube defects
Citação
CABRAL, Amanda Rodrigues et al. A suplementação de ácido fólico na prevenção de disfunções autonômicas cardíacas e de anomalias do tubo neural: uma revisão sistemática. Revista Brasileira de Nutrição Clínica, Porto Alegre, v. 30, n. 4, p. 344-353, 2015.