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dc.creatorOliveira, Stela Ramirez de-
dc.creatorTaveira, Stephânia Fleury-
dc.creatorMarreto, Ricardo Neves-
dc.creatorDiniz, Danielle Guimarães Almeida-
dc.creatorLima, Eliana Martins-
dc.creatorValadares, Marize Campos-
dc.identifier.citationOLIVEIRA, STELA R. de et al. Preparation and characterization of solid oral dosage forms containing soy isoflavones. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 1, p. 175-182, Jan./Feb. 2013.pt_BR
dc.description.abstractSoy isoflavones have been extensively used for menopausal symptoms and prevention of hormone-related cancer, osteoporosis and cardiovascular diseases. Commercially available forms of isoflavones include supplements, capsules and tablets. However, the non-standardization of soy isoflavones extracts and different dissolution profiles of these solid dosage forms highlight the need of additional studies on the development of well characterized pharmaceutical dosage forms of isoflavones. In this work, immediate release oral tablets of soy isoflavones were obtained and evaluated. Genistein and daidzein, were the main constituents of the dried soy extract. Preparation of the tables was accomplished in a rotary tableting machine following either a dry mixture for direct compression or wet granulation with different excipients. Powder, granules and tablets were evaluated for several parameters, including flow properties, Carr and Hausner indexes, hardness, friability, disintegration time and drug release profile. Also, a fast and validated HPLC analytical method for both genistein and daidzein was developed. Formulations containing sodium croscarmellose and sodium dodecyl sulfate resulted in better flowability as indicated by the flow rate and angle of repose, faster disintegration time and immediate release dissolution profile.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectIsoflavone extractpt_BR
dc.titlePreparation and characterization of solid oral dosage forms containing soy isofl avonespt_BR
dc.publisher.departmentFaculdade de Farmácia - FF (RG)pt_BR
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