Avaliação comparativa dos efeitos tóxico-genéticos da própolis em células somáticas de drosophila melanogaster, portadoras de diferentes níveis de enzimas de metabolização

Resumo

This study aimed to evaluate the genotoxic and anti-cytotoxic activities of propolis on mitomycin C (MMC) induced lesions using Drosophila melanogaster strains with different cytochrome P-450 metabolic enzymes expression levels. The wing somatic mutation and recombination test (SMART) was used and supplied a wide spectrum of information concerning genic and cromossomal mutations and/ or genetic recombinations. The results indicated that propolis acted as a direct modulator on cytotoxic effects induced by MMC. Furthermore, it was demonstrated that propolis did not induce mutagenic and/ or recombinagenic events in D. melanogaster somatic cells. The data showed in this paper corroborates the ones described in the literature, contributing to determine the protective activity of propolis when administrated with genotoxic agents presenting different mechanisms of action.

Descrição

Palavras-chave

Anticitotóxico, Drosophila melanogaster, Mutagênese, Própolis, Teste SMART, Anticytotoxic

Citação

OLIVEIRA, Igor Gomes de; PEREIRA, Karla de Castro; GUIMARÃES, Carolina Costa; MORAES, Torquato Naves; LEE, Chen Chen; CUNHA, Kênya Silva. Avaliação comparativa dos efeitos tóxico-genéticos da própolis em células somáticas de drosophila melanogaster, portadoras de diferentes níveis de enzimas de metabolização. Revista de Biologia Neotropical, Goiânia, v. 4, n. 1, p. 64-69, jan./jun. 2007. Disponível em: <https://www.revistas.ufg.br/RBN/article/view/4658/4057>.