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dc.creatorCarneiro, Marcella Lemos Brettas-
dc.creatorPorfírio, Elaine Paulucio-
dc.creatorOtake, Andréia Hanada-
dc.creatorChammas, Roger-
dc.creatorBáo, Sônia Nair-
dc.creatorGuillo, Lidia Andreu-
dc.date.accessioned2019-02-15T13:03:19Z-
dc.date.available2019-02-15T13:03:19Z-
dc.date.issued2010-04-
dc.identifier.citationCARNEIRO, Marcella Lemos Brettas et al. Morphological alterations and Go/G1 cell cycle arrest indiced by curucmin in human SK-MEL-37 melanoma cells. Brazilian Archives of Biology and Technology, v. 53, n. 2, p. 343-352, Mar./Apr. 2010.pt_BR
dc.identifier.issn1516-8913-
dc.identifier.issne- 1678-4324-
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/17064-
dc.description.abstractThe aim of this work was to study the effect of curcumin on cell cycle in the human SK-MEL-37 melanoma cell line. In addition, morphological and structural analyses were also performed. Flow cytometric analysis showed a G0/G1 arrest at 5 μM after 24 h exposure and a concentration-dependent increase in the proportion of sub-G0 hypodiploid cells. Typical apoptotic events were also observed by the fluorescence microscopy, transmission and scanning electronic microscopy. Loss of mitochondrial membrane potential was not detected. Results suggested that curcumin could arrest human melanoma cells at G0/G1 phase and induce a mitochondrial-independent apoptotic pathway.pt_BR
dc.language.isoengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCurcuminpt_BR
dc.subjectCell cyclept_BR
dc.subjectMelanoma cellspt_BR
dc.subjectApoptosispt_BR
dc.titleMorphological alterations and Go/G1 cell cycle arrest indiced by curucmin in human SK-MEL-37 melanoma cellspt_BR
dc.typeArtigopt_BR
dc.publisher.countryBrasilpt_BR
dc.identifier.doi10.1590/S1516-89132010000200013-
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
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