Evaluation of clinical and laboratory variables associated with anemia in pediatric patients on hemodialysis
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Data
2015
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Resumo
Objective: To identify the occurrence of anemia in pediatric patients on hemodialysis and the
association between hemoglobin levels and anemia in CKD-related variables.
Methods: This was a retrospective study. Patients aged up to 18 years with chronic kidney
disease undergoing hemodialysis at this service between January of 2009 and December of 2010
were selected. Clinical and laboratory data were obtained from medical records. Statistical
analysis was performed with chi-squared test, Student’s t-test and general estimating equations
(GEE) using SPSS 20.0, assuming a significance level of 5%.
Results: A total of 357 medical records depicting the monthly evolution of 29 patients were
analyzed. The most common etiology for chronic kidney disease was malformations of the geni-
tourinary tract (28%). Hemoglobin showed a mean (standard deviation) value of 9.20 (1.8) g/dL,
with the occurrence of anemia in 65.3% of cases. Anemia was associated with hospitalization;
antibiotic use; transfusion; use of intravenous iron hydroxide; low values of creatinine, hema-
tocrit, and albumin; and high values of ferritin, aluminum, and equilibrated Kt/V (p < 0.05).
The odds ratio for anemia with the use of intravenous iron hydroxide was 0.36 (95% CI: 0.25 to
0.89), i.e., a 2.78-fold higher chance of developing anemia without the use of this medication.
Conclusions: Anemia predominated in children and adolescents with chronic kidney disease;
intravenous iron hydroxide use was a protective factor.
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Palavras-chave
Anemia, Renal failure, Child, Kidney dialysis, Adolescent, Anemia, Criança, Adolescente, Diálise renal, Insuficiência renal
Citação
FREITAS, Johnathan S. de et al. Evaluation of clinical and laboratory variables associated with anemia in pediatric patients on hemodialysis. Jornal de Pediatria, Porto Alegre, v. 91, n. 1, p. 87-92, 2015.