Efeito analgésico do piroxicam para tratamento de dor aguda induzida
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Data
2011-04
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Resumo
BACKGROUND AND OBJECTIVES: Pain and inflam-
mation represent fundamental pathophysiological process-
es to eliminate the injurious stimuli to the living organism.
The aim of this study was to compare the effectiveness of
the reference product Feldene®, (FLX) with a similar prod-
uct for the treatment of acute sensory pain induced in mice.
METHOD: Pre-clinical testing with 18 female albino mice (Mus
musculus) Swiss-Webster variety, young and healthy, were divided
into 3 groups of 6 animals each, to evaluate the analgesic effect
of piroxicam, comparing the reference products and similar. The
treatment consisted of 1mg/kg for groups A: piroxicam reference,
B: control (placebo-vehicle) and C: similar to piroxicam (FLX). Af-
ter 1h of treatment administration, was given 0.6% acetic acid (0.1
mL/10g) by i.p. and the counting of contortions for 30 minutes.
Data were expressed as means and standard deviations of means.
RESULTS: There was a significant difference in the number of
contortions to the reference product 15.50 ± 3.50, 26.67 ± 7.87
similar products, compared to 146.83 ± 8.82 placebo. We noted
the reduction in the number of contortions when compared to
the reference product (90%) with similar product (82%). We
considered p < 0.05 significant difference (Tukey test).
CONCLUSION: As expected, the piroxicam proved effective
to control the writhing. The reference product showed the best
results obtained since a smaller number of contortions and its
average was considerable when compared to the like product.
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Analgésico, Piroxicam, Dor abdominal, Abdominal pain, Analgesics, Piroxicam
Citação
SANTOS, Hugo Campos de Oliveira et al. Efeito analgésico do piroxicam para tratamento de dor aguda induzida. Revista da Sociedade Brasileira de Clínica Médica, São Paulo, v. 9, n. 2, p. 117-120, mar./abr. 2011.