Estudo comparativo da eficácia de colírios antiinflamatórios não esteróides na manutenção da dilatação pupilar durante a cirurgia de catarata
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Data
2003
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Background and Purpose: Nonsteroidal antiinflammatory
drugs, with antiprostaglandin effect, have been used in the
preoperative period of cataract surgery for maintenance of
mydriasis during the surgery. Unfortunately, the ideal anti-
prostaglandin has yet to be introduced. This study is a trans-
versal cut, randomized, placebo-group and double-masked
clinical trial comparing the efficacy of ketorolac tromethamine,
flurbiprofen sodium and diclofenac sodium with a placebo
(hypromellose) in maintaining mydriasis during surgery. Me-
thods: One hundred sixteen patients, undergoing extracapsu-
lar cataract extraction with intraocular lens implantation, were
randomly assigned to four groups, which had the same routi-
ne for dilation and use of antiprostaglandins. Group I received
ketorolac tromethamine; group II, flurbiprofen; group III, di-
clofenac and group IV, control group, hypromellose. The pu-
pillary data were obtained through an objective questionnaire
answered by each surgeon after surgery. Results: Group I
was statistically different from placebo regarding maintenance
of dilation during surgey. The difference was statistically
significant between GI and the other regarding sufficient my-
driasis for the beginning of surgery and intraoperative miosis.
Flurbiprofen and diclofenac were not statistically different
and also when they were compared to the placebo as regards
the commented above parameters. Conclusions: Ketorolac
tromethamine was more effective than other antiprostaglan-dins and placebo considering the tested parameters. Flurbi-
profen and diclofenac were better than placebo considering
percentual values, with no statistical difference. An increase
in the number of our sample as well as other multicentric
studies will help to establish a definitive role for antiprosta-
glandins in maintaining mydriasis during surgery.
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Soluções oftálmicas, Adulto, Extração de catarata, Estudo comparativo, Pupila/efeito de drogas, Eficácia, Antiinflamatórios não-esteróide/uso terapêutico, Ophthalmic solutions
Citação
TOMÁS, Rafael Naves et al. Estudo comparativo da eficácia de colírios antiinflamatórios não esteróides na manutenção da dilatação pupilar durante a cirurgia de catarata. Arquivos Brasileiros de Oftalmologia, São Paulo, v. 66, n. 6, p. 819-822, 2003.