Estudo comparativo de duas técnicas farmacopéicas de avaliação da atividade antimicrobiana dos fármacos: nistatina, eritromicina, neomicina e gentamicina
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Data
2004-06
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Resumo
Through the diffusion techniques in culture media with
paper disc and stainless steel cylinders the antimicrobial
activity in 123 pharmaceutical preparations was
evaluated: nystatin (43 samples of vaginal cream),
erythromycin (14 samples of tablets and 9 of oral
suspension), gentamicin (33 samples of injectable liquid)
and neomycin (24 samples of cream of topic use), against
the microorganisms: Saccharomyces cerevisiae ATCC
2601 to nystatin; Staphylococcus epidermidis 12228 to
gentamicin and neomycin, and Micrococcus luteus ATCC
9341 to erythromycin. The preparation of the test
organisms, standard solution, test solutions and culture
media in both methods followed the recomendations of
Brazilian Pharmacopoeia IV (1988) and United States
Pharmacopoeia 24 (2000). The results was statically
analysed by tests of Fisher (p=0,05) and Student
(p=0,05). Among the 43 samples of vaginal cream nystatin
analysed, checked out by the Student’s test, differences of
antimicrobial activity between methods of disc and
cylinder were observed. However, the Fisher’s test does
not presented difference. The samples of erythromycin,
gentamicin and neomycin did not show any difference
when submitted to Fisher and Student tests in conclusion,
to the erythromycin, gentamicin, neomycin and nystatin,
the analysis of antimicrobial activity by the technique of
paper discs can substitute the technique of the cylinders of
stainless steel.
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Atividade antimicrobiana, Nistatina, Eritromicina, Gentamicina, Neomicina, Antimicrobial activity, Nystatin, Erythromycin, Neomicyn, Gentamicin
Citação
VIDAL, Tatiane Margato et al. Estudo comparativo de duas técnicas farmacopeicas de avaliação da atividade antimicrobiana dos farmacos: nistatina, eritromicina, neomicina e gentamicina. Revista Brasileira de Ciências Farmacêuticas, São Paulo, v. 40, n. 2, p. 219-227, abr./jun. 2004.