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Tipo do documento: Artigo
Título: Sepsis-induced acute kidney injury: biomarkers for diagnosis
Autor: Rodrigues, Vanessa Marcelino
Freitas, Ana Caroline Silva de
Figueiredo, Maria José
Machado, Juliana Reis
Menezes, Liliana Borges de
Soave, Danilo Figueiredo
Celes, Mara Rubia Nunes
Abstract: Sepsis is a major global health problem leading to the increased incidence of death in intensive care units. In recent years, despite technological advances, the number of cases has grown significantly. Among the main complications presented by septic patients, acute renal dysfunction is largely responsible for the high mortality rate. Initially, the reduction of renal function is associated with focal tubular injury with preserved glomerular morphology and systemic hemodynamic alterations. During sepsis development, the progressive decrease in urinary volume and reduction of the glomerular filtration rate associated with increased serum levels of urea and creatinine are considered classic markers of severe kidney injury. Despite the valuable role of these serum markers regarding renal function, these data provide an incomplete scenario of the patient, since many renal disorders may occur in individuals with increased plasma concentrations of urea and creatinine. Taking into account the important role of systemic inflammatory processes in the development of acute kidney injury induced by sepsis, the search for new markers presenting high sensitivity and specificity capable of detecting early renal injury is still necessary. Thus, the present review summarizes important aspects of pathophysiology of acute kidney dysfunction induced by sepsis and presents an updated view of possible new biomarkers associated with the development of acute kidney injury. Understanding these markers allows important advances leading to new therapeutic approaches, indicating a new horizon in the diagnosis and treatment of acute kidney injury in sepsis.
Palavras-chave: Sepsis
Acute kidney injury
Diagnostic biomarkers
País: Brasil
Instituição: Ruy de Souza Lino Junior
Sigla da instituição: UFG
Unidade acadêmica: Instituto de Patologia Tropical (IPTSP) - RG
Citação: RODRIGUES, Vanessa Marcelino; FREITAS, Ana Caroline Silva de; FIGUEIREDO, Maria José; MACHADO, Juliana Reis; MENEZES, Liliana Borges de; SOAVE, Danilo Figueiredo; CELES, Mara Rubia Nunes. Revista de Patologia Tropical, Goiânia, v. 46, n. 3, p. 221-232, jul./set. 2018. Disponível em:
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.5216/rpt.v46i3.49681
Identificador do documento: 10.5216/rpt.v46i3.49681
Data de publicação: Set-2017
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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