Incidence of ventricular arrhythmias after stem cell therapy in patients with Chagas cardiomyopathy
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Data
2014
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Background: Treatment with stem cells in several cardiomyopathies may be related to the increase in arrhythmias.
Objectives: To determine whether intracoronary injection of stem cells in patients with Chagas cardiomyopathy is
associated with increased incidence of ventricular arrhythmias, compared to the Control Group.
Methods: A retrospective cohort study that evaluated the medical records of 60 patients who participated in a previous
cross-sectional study. The following data were collected: age, gender, drugs used and Holter variables that demonstrated
the presence of arrhythmias. Holter was performed in four stages: randomization, 2, 6 and 12 months segments. The
Control Group received medical treatment and intracoronary injection of placebo and the Study Group had drug
treatment and autologous stem cell implant.
Results: There was no difference between Control Group and Study Group when analyzing the arrhythmia criteria. In
the intra-group analysis, significant difference was found between the Holter tests of the Study Group for the variable
total ventricular premature beats when compared with baseline, with p = 0.014 between Holter at randomization
and Holter at 2 months, p = 0.004 between Holter at randomization and Holter at 6 months, and p = 0.014 between
Holter at randomization and Holter at 12 months. The variable non-sustained ventricular tachycardia between Holter at
randomization and Holter at 6 months showed p = 0.036.
Conclusion: The intracoronary injection of stem cells did not increase the incidence of ventricular arrhythmias in
patients with Chagas cardiomyopathy compared to the Control Group.
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Palavras-chave
Arrhythmias, Chagas cardiomyopathy, Cardiac, Stem cell transplantation
Citação
SOUZA, Adriana Sebba Barroso de et al. Incidence of ventricular arrhythmias after stem cell therapy in patients with Chagas cardiomyopathy. Arquivos Brasileiros de Cardiologia, Rio de Janeiro, v. 102, n. 5, p. 489-494, 2014.