Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV)
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Data
2011
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Resumo
Human papillomavirus (HPV) has been cited as a
possible initiating agent in the pathogenesis of oral cancer.
However, the literature tends to be both controversial and
inconclusive about the prevalence of HPV and its potential
for proliferation in oral squamous cell carcinoma (SCC).
The aim of this study was to investigate the cellular
proliferation and the presence of HPV in SCC and
verrucous carcinoma (VC). Forty-seven samples of SCC
were selected and divided into three groups: 39 SCC, 8 VC,
and 9 of normal mucosa (control-CT). Quantitative analyses
of all groups showed a greater expression of PCNA,
followed by Ki-67 and cyclin B1. A significant difference
was observed in cyclin B1 expression in the SCC group
compared with VC. PCNA, Ki-67, and cyclin B1 were
statistically significant when comparing the SCC and CT
groups. However, when SCC and VC were compared, there
was no difference in Ki-67 expression. Our results showed
that only cyclin B1 had an association with histological
grade, and that poorly differentiated tumors presented a
higher expression of cyclin B1. Therefore, considerable
differences in the cellular proliferation between SCC and
VC were observed, and no correlation with HPV was
established, since all samples were negative for HPV.
Descrição
Palavras-chave
Oral squamous cell carcinoma, HPV, Oral verrucous carcinoma, Cyclin B1, PCNA, Ki-67
Citação
SPÍNDULA-FILHO, José Vieira et al. Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV). Tumor Biology, New York, v. 32, n. 2, p. 409-416, 2011.