Impact of sex on hyperalgesia induced by sleep loss
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Data
2011
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Resumo
This study evaluated the impact of sex on the short term consequences of different periods of sleep
deprivation and the effect of the respective sleep recovery periods on nociceptive responses. Male and female
C57BL/6J mice were assigned to the following groups: paradoxical sleep deprived (PSD) for 72 h, sleep
restricted (SR) for 15 days, exposed to respective recovery periods for 24 h, or untreated home-cage controls
(CTRL). Mice were submitted to a noxious thermal stimulus to evaluate their nociceptive response after PSD,
SR, or recovery periods. Blood was collected for hormonal analysis. The nociceptive response was significantly
lower in PSD and SR mice compared to CTRL animals, regardless of the sex. However, SR females had a lower
paw withdrawal threshold than males. Sleep recovery was able to restore normal nociceptive sensitivity after
PSD in both sexes. The hyperalgesia induced by SR was not reversed by sleep rebound. In females, low
concentrations of estradiol were found after SR, and these concentrations continued to decrease after
24 hours of sleep recovery. The PSD male mice exhibited higher concentrations of corticosterone than the
CTRL and SR male mice. Corticosterone levels were not affected by SR. Our study revealed that PSD and
SR induce hyperalgesia in mice. The SR groups showed marked changes in the nociceptive response, and
the females were more sensitive to these alterations. This finding indicates that, although different periods
of sleep deprivation change the nociceptive sensitivity in male and female mice, sex could influence
hyperalgesia induced by chronic sleep loss.
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Sleep deprivation, Hormones, Mice, Hyperalgesia, Sex differences, Corticosterone, Estradiol
Citação
ARAUJO, P. et al. Impact of sex on hyperalgesia induced by sleep loss. Hormones and Behavior, New York, v. 59, p. 174-179, 2011.