Anti-inflammatory, antinociceptive, and sedating effects of lafoensia pacari aqueous extract
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Data
2008
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Resumo
The acetic acid–induced abdominal writhing, the tail flick,
and the croton oil–induced mouse ear edema tests were
used to study the anti-inflammatory effects of the aqueous
extract from Lafoensia pacari A. St.-Hil. (Lythraceae) stem
bark. Pentobarbital-induced sleeping timewas used to study
the central nervous system depressant effect of the extract.
The aqueous extract caused a dose-dependent inhibition of
acetic acid–induced abdominal writhing and ear edema formation
and produced a significant (p < 0.05) dose-related
increase in the duration of sleep. The results suggest that
Lafoensia pacari stem bark contains compounds with antiinflammatory,
analgesic, and central depressant actions.
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Analgesic activity, Anti-inflammatory effect, Central depressant actions, Lafoensia pacari, Ear edema, Lythraceae
Citação
1-MATOS, Lecia G. de et al. Anti-inflammatory, antinociceptive, and sedating effects of lafoensia pacari aqueous extract. Pharmaceutical Biology, London, v. 46, n. 5, p. 341-346, 2008.