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Tipo do documento: Artigo
Título: Dynamics of macrophage cell populations during murine pulmonary tuberculosis
Autor: Gonzalez Juarrero, Mercedes
Shim, Tae Sun
Kipnis, Andre
Junqueira-Kipnis, Ana Paula
Orme, Ian M.
Abstract: tuberculosis. In this investigation we used flow cytometric analysis to define macrophage populations entering the airways and lung tissues of infected mice. We demonstrate that by the judicious use of cell surface markers, especially CD11b and CD11c, several cell populations can be distinguished, allowing cell sorting and morphological definition. Primary populations of CD11b /CD11c /high were defined as alveolar macrophages, CD11bhigh/CD11c /high as dendritic cells, and CD11b /mid/CD11c /mid as small macrophages or monocytes, and changes in the activation phenotype of these populations were followed over the early course of the infection. In further studies, these cell populations were compared with cells harvested during the chronic stage of the disease. During the chronic stage of infection, Ag-presenting class II molecules and activation markers were poorly expressed on dendritic, small macrophage, and monocyte cell populations, which may have important implications for the breakdown of the lesions during reactivation disease. This analytical approach may facilitate the further characterization of macrophage populations entering into the lung tissues and their relative contributions to host resistance to tuberculosis infection.
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: GONZALES-JUARRERO, Mercedes et al. Dynamics of macrophage cell populations during murine pulmonary tuberculosis. The Journal of Immunology, Bethesda, v. 171, n. 6, p. 3128-3135, 2003.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4049/jimmunol.171.6.3128
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Identificador do documento: 10.4049/jimmunol.171.6.3128
Data de publicação: 2003
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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