In vivo il-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice
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2002
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The production of immunosuppressive cytokines, such as IL-10 and TGF- , has been documented in individuals diagnosed with
active tuberculosis. In addition, IL-10 production is increased within the lungs of mice that have chronic mycobacterial infection.
Therefore, we hypothesized that the down-regulatory properties of IL-10 might contribute to the reactivation of chronic Mycobacterium
tuberculosis infection in mice. To determine the influence of IL-10 on the course of infection, transgenic mice producing
increased amounts of IL-10 under the control of the IL-2 promotor were infected with M. tuberculosis via the respiratory route.
Mice that overexpressed IL-10 showed no increase in susceptibility during the early stages of infection, but during the chronic
phase of the infection showed evidence of reactivation tuberculosis with a highly significant increase in bacterial numbers within
the lungs. Reactivation was associated with the formation of macrophage-dominated lesions, decreased mRNA production for TNF
and IL-12p40, and a decrease in Ag-specific IFN- secretion. These data support the hypothesis that IL-10 plays a pivotal role
during the chronic/latent stage of pulmonary tuberculosis, with increased production playing a potentially central role in promoting
reactivation tuberculosis.
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TURNER, Joanne et al. In vivo il-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. The Journal of Immunology, Rockville, v. 169, n. 11, p. 6343-6351, 2002.