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Tipo do documento: Artigo
Título: In vivo il-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice
Autor: Turner, Joanne
Gonzalez Juarrero, Mercedes
Ellis, Debi L.
Basaraba, Randy J.
Kipnis, Andre
Orme, Ian M.
Cooper, Andrea M.
Abstract: The production of immunosuppressive cytokines, such as IL-10 and TGF- , has been documented in individuals diagnosed with active tuberculosis. In addition, IL-10 production is increased within the lungs of mice that have chronic mycobacterial infection. Therefore, we hypothesized that the down-regulatory properties of IL-10 might contribute to the reactivation of chronic Mycobacterium tuberculosis infection in mice. To determine the influence of IL-10 on the course of infection, transgenic mice producing increased amounts of IL-10 under the control of the IL-2 promotor were infected with M. tuberculosis via the respiratory route. Mice that overexpressed IL-10 showed no increase in susceptibility during the early stages of infection, but during the chronic phase of the infection showed evidence of reactivation tuberculosis with a highly significant increase in bacterial numbers within the lungs. Reactivation was associated with the formation of macrophage-dominated lesions, decreased mRNA production for TNF and IL-12p40, and a decrease in Ag-specific IFN- secretion. These data support the hypothesis that IL-10 plays a pivotal role during the chronic/latent stage of pulmonary tuberculosis, with increased production playing a potentially central role in promoting reactivation tuberculosis.
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: TURNER, Joanne et al. In vivo il-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. The Journal of Immunology, Rockville, v. 169, n. 11, p. 6343-6351, 2002.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4049/jimmunol.169.11.6343
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Identificador do documento: 10.4049/jimmunol.169.11.6343
Data de publicação: 2002
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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